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Retatrutide activates three metabolic receptors: GLP-1 (appetite suppression and glucose control), GIP (fat metabolism and insulin regulation), and glucagon (energy expenditure and fat oxidation)
(March 2025)
Clinical trials demonstrating semaglutides effectiveness typically ran for 68 weeks (approximately 16 months) or longer, with average weight loss of 14.9% of total body weight
Early evidence on lipid outcomes is encouraging though long-term data is still accumulating
Both medications are most problematic during dose escalation phases and tend to improve as the body adapts
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